Bruce Kristal

Bruce Kristal, Ph.D.

Associate Professor of Medicine

617-525-3280

Faculty Information
Publications

Harvard Title

Associate Professor of Medicine

Administrative and Hospital Titles

Lead Investigator, Division of Sleep and Circadian Disorders, Departments of Medicine and Neurology, Brigham and Women's Hospital

Address

221 Longwood Ave, LM322B, Boston, MA 02115

Publications View

Reactive gamma-ketoaldehydes formed via the isoprostane pathway disrupt mitochondrial respiration and calcium homeostasis.

Authors: Stavrovskaya IG, Baranov SV, Guo X, Davies SS, Roberts LJ, Kristal BS.
Free Radic Biol Med 2010-08-15
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Mass-spectrometry-based metabolomics: limitations and recommendations for future progress with particular focus on nutrition research.

Authors: Scalbert A, Brennan L, Fiehn O, Hankemeier T, Kristal BS, van Ommen B, Pujos-Guillot E, Verheij E, Wishart D, Wopereis S.
Metabolomics 2009-12-01
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Methazolamide and melatonin inhibit mitochondrial cytochrome C release and are neuroprotective in experimental models of ischemic injury.

Authors: Wang X, Figueroa BE, Stavrovskaya IG, Zhang Y, Sirianni AC, Zhu S, Day AL, Kristal BS, Friedlander RM.
Stroke 2009-05-01
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Inhibitors of cytochrome c release with therapeutic potential for Huntington's disease.

Authors: Wang X, Zhu S, Pei Z, Drozda M, Stavrovskaya IG, Del Signore SJ, Cormier K, Shimony EM, Wang H, Ferrante RJ, Kristal BS, Friedlander RM.
J Neurosci 2008-09-17
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Metabolite identification using a nanoelectrospray LC-EC-array-MS integrated system.

Authors: Schiavo S, Ebbel E, Sharma S, Matson W, Kristal BS, Hersch S, Vouros P.
Anal Chem 2008-08-01
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Nortriptyline protects mitochondria and reduces cerebral ischemia/hypoxia injury.

Authors: Zhang WH, Wang H, Wang X, Narayanan MV, Stavrovskaya IG, Kristal BS, Friedlander RM.
Stroke 2008-02-01
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Kinetic model for Ca2+-induced permeability transition in energized liver mitochondria discriminates between inhibitor mechanisms.

Authors: Baranov SV, Stavrovskaya IG, Brown AM, Tyryshkin AM, Kristal BS.
J Biol Chem 2008-01-11
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Metabolomics: a global biochemical approach to drug response and disease.

Authors: Kaddurah-Daouk R, Kristal BS, Weinshilboum RM.
Annu Rev Pharmacol Toxicol 2008-01-01
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Branched chain keto-acids exert biphasic effects on alpha-ketoglutarate-stimulated respiration in intact rat liver mitochondria.

Authors: Shestopalov AI, Kristal BS.
Neurochem Res 2007-12-01
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Biological variability dominates and influences analytical variance in HPLC-ECD studies of the human plasma metabolome.

Authors: Shurubor YI, Matson WR, Willett WC, Hankinson SE, Kristal BS.
BMC Clin Pathol 2007-11-12
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