Bruce Kristal

Bruce Kristal, Ph.D.

Associate Professor of Medicine
617-525-3280
Harvard Catalyst Profile
Harvard Title

Associate Professor of Medicine

Administrative and Hospital Titles

Lead Investigator, Division of Sleep and Circadian Disorders, Departments of Medicine and Neurology, Brigham and Women's Hospital

Address

221 Longwood Ave, LM322B, Boston, MA 02115

Publications View
Reactive gamma-ketoaldehydes formed via the isoprostane pathway disrupt mitochondrial respiration and calcium homeostasis.
Authors: Stavrovskaya IG, Baranov SV, Guo X, Davies SS, Roberts LJ, Kristal BS.
Free Radic Biol Med
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Mass-spectrometry-based metabolomics: limitations and recommendations for future progress with particular focus on nutrition research.
Authors: Scalbert A, Brennan L, Fiehn O, Hankemeier T, Kristal BS, van Ommen B, Pujos-Guillot E, Verheij E, Wishart D, Wopereis S.
Metabolomics
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Methazolamide and melatonin inhibit mitochondrial cytochrome C release and are neuroprotective in experimental models of ischemic injury.
Authors: Wang X, Figueroa BE, Stavrovskaya IG, Zhang Y, Sirianni AC, Zhu S, Day AL, Kristal BS, Friedlander RM.
Stroke
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Inhibitors of cytochrome c release with therapeutic potential for Huntington's disease.
Authors: Wang X, Zhu S, Pei Z, Drozda M, Stavrovskaya IG, Del Signore SJ, Cormier K, Shimony EM, Wang H, Ferrante RJ, Kristal BS, Friedlander RM.
J Neurosci
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Metabolite identification using a nanoelectrospray LC-EC-array-MS integrated system.
Authors: Schiavo S, Ebbel E, Sharma S, Matson W, Kristal BS, Hersch S, Vouros P.
Anal Chem
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Nortriptyline protects mitochondria and reduces cerebral ischemia/hypoxia injury.
Authors: Zhang WH, Wang H, Wang X, Narayanan MV, Stavrovskaya IG, Kristal BS, Friedlander RM.
Stroke
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Kinetic model for Ca2+-induced permeability transition in energized liver mitochondria discriminates between inhibitor mechanisms.
Authors: Baranov SV, Stavrovskaya IG, Brown AM, Tyryshkin AM, Kristal BS.
J Biol Chem
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Metabolomics: a global biochemical approach to drug response and disease.
Authors: Kaddurah-Daouk R, Kristal BS, Weinshilboum RM.
Annu Rev Pharmacol Toxicol
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Branched chain keto-acids exert biphasic effects on alpha-ketoglutarate-stimulated respiration in intact rat liver mitochondria.
Authors: Shestopalov AI, Kristal BS.
Neurochem Res
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Biological variability dominates and influences analytical variance in HPLC-ECD studies of the human plasma metabolome.
Authors: Shurubor YI, Matson WR, Willett WC, Hankinson SE, Kristal BS.
BMC Clin Pathol
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