Doyle Research Group - Systems Biology and Biomedical Control

John A. Paulson School of Engineering and Applied Sciences, Harvard University
Director: Dean Francis J. Doyle III, PhD

The Doyle Research Group uses a systems biology approach to develop models for the control of biological systems, including the circadian system and the artificial pancreas.  To better understand underlying mechanisms of the circadian system, the group has created physiologically based models at the molecular level of the core transcriptional-translational oscillator.  These models allow for an exploration of how oscillations develop from genetic regulatory circuits and provide the basis of analysis for limit cycle behavior and robustness.  In particular, such models have made it possible to elucidate the mechanism of action of small molecules, including KL001, and provide predictions for other effective targets for manipulating the circadian oscillator.  Work has applied sensitivity analysis and model predictive control techniques to understand the responses of the circadian system to these inputs and to investigate how to control various outputs of the system including phase, amplitude, and population synchrony.

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Mona Tousian

Research Unit Address 

Frank Doyle Research Group
Harvard John A. Paulson School of Engineering & Applied Sciences
Maxwell Dworkin
33 Oxford Street
Cambridge, MA 02138