Elizabeth B. Klerman, M.D., Ph.D.
Professor of Neurology, Massachusetts General Hospital
Administrative Ofcr (Faculty), Harvard Medical School
Harvard Title
Professor of Neurology
Administrative and Hospital Titles
Research Investigator, Division of Neurophysiology, Sleep Unit, Department of Neurology, Massachusetts General Hospital
Physician, Division of Sleep and Circadian Disorders, Department of Medicine, Brigham and Women's Hospital
Director, Analytic and Modeling Unit, Division of Sleep and Circadian Disorders, Brigham and Women's Hospital
Other Affiliations
Visiting Scientist, Massachusetts Institute of Technology
Address
100 Cambridge Street
20th floor- MGH Neurology
55 Fruit St
Boston MA 02114
Publications View
Melatonin agonist tasimelteon (VEC-162) for transient insomnia after sleep-time shift: two randomised controlled multicentre trials.
Authors: Rajaratnam SM, Polymeropoulos MH, Fisher DM, Roth T, Scott C, Birznieks G, Klerman EB.
Lancet
View full abstract on Pubmed
Lancet
View full abstract on Pubmed
Age-related reduction in the maximal capacity for sleep--implications for insomnia.
Measuring melatonin in humans.
Authors: Benloucif S, Burgess HJ, Klerman EB, Lewy AJ, Middleton B, Murphy PJ, Parry BL, Revell VL.
J Clin Sleep Med
View full abstract on Pubmed
J Clin Sleep Med
View full abstract on Pubmed
A physiologically based mathematical model of melatonin including ocular light suppression and interactions with the circadian pacemaker.
Authors: St Hilaire MA, Gronfier C, Zeitzer JM, Klerman EB.
J Pineal Res
View full abstract on Pubmed
J Pineal Res
View full abstract on Pubmed
Addition of a non-photic component to a light-based mathematical model of the human circadian pacemaker.
Authors: St Hilaire MA, Klerman EB, Khalsa SB, Wright KP, Czeisler CA, Kronauer RE.
J Theor Biol
View full abstract on Pubmed
J Theor Biol
View full abstract on Pubmed
Uncovering physiologic mechanisms of circadian rhythms and sleep/wake regulation through mathematical modeling.
Authors: Kronauer RE, Gunzelmann G, Van Dongen HP, Doyle FJ, Klerman EB.
J Biol Rhythms
View full abstract on Pubmed
J Biol Rhythms
View full abstract on Pubmed
Developing mathematical models of neurobehavioral performance for the "real world".
On mathematical modeling of circadian rhythms, performance, and alertness.
Elevated body temperature during sleep in orexin knockout mice.
Authors: Mochizuki T, Klerman EB, Sakurai T, Scammell TE.
Am J Physiol Regul Integr Comp Physiol
View full abstract on Pubmed
Am J Physiol Regul Integr Comp Physiol
View full abstract on Pubmed
Development of a two-dimension manifold to represent high dimension mathematical models of the intracellular Mammalian circadian clock.