Dr. Shaun Purcell

Shaun Purcell, Ph.D.

617-525-8039
Harvard Catalyst Profile
Harvard Title

Associate Professor of Psychiatry

Other Affiliations

Department of Psychiatry, Brigham and Women's Hospital

Senior Associate, Broad Institute, Stanley Center for Psychiatric Research

Address

Brigham and Women's Hospital
Dept. of Psychiatry, Rm 394
221 Longwood Ave  
Boston MA 02115

Publications View
Partitioning heritability of regulatory and cell-type-specific variants across 11 common diseases.
Authors: Gusev A, Lee SH, Trynka G, Finucane H, Vilhjálmsson BJ, Xu H, Zang C, Ripke S, Bulik-Sullivan B, Stahl E, Kähler AK, Hultman CM, Purcell SM, McCarroll SA, Daly M, Pasaniuc B, Sullivan PF, Neale BM, Wray NR, Raychaudhuri S, Price AL.
Am J Hum Genet
View full abstract on Pubmed
No association between RORA polymorphisms and PTSD in two independent samples.
Authors: Guffanti G, Ashley-Koch AE, Roberts AL, Garrett ME, Solovieff N, Ratanatharathorn A, De Vivo I, Dennis M, Ranu H, Smoller JW, Liu Y, Purcell SM, Beckham J, Hauser MA, Koenen KC.
Mol Psychiatry
View full abstract on Pubmed
A framework for the interpretation of de novo mutation in human disease.
Authors: Samocha KE, Robinson EB, Sanders SJ, Stevens C, Sabo A, McGrath LM, Kosmicki JA, Rehnström K, Mallick S, Kirby A, Wall DP, MacArthur DG, Gabriel SB, DePristo M, Purcell SM, Palotie A, Boerwinkle E, Buxbaum JD, Cook EH, Gibbs RA, Schellenberg GD, Sutcliffe JS, Devlin B, Roeder K, Neale BM, Daly MJ.
Nat Genet
View full abstract on Pubmed
Copy number variation in schizophrenia in Sweden.
Authors: Szatkiewicz JP, O'Dushlaine C, Chen G, Chambert K, Moran JL, Neale BM, Fromer M, Ruderfer D, Akterin S, Bergen SE, Kähler A, Magnusson PK, Kim Y, Crowley JJ, Rees E, Kirov G, O'Donovan MC, Owen MJ, Walters J, Scolnick E, Sklar P, Purcell S, Hultman CM, McCarroll SA, Sullivan PF.
Mol Psychiatry
View full abstract on Pubmed
Common variants on Xq28 conferring risk of schizophrenia in Han Chinese.
Authors: Wong EH, So HC, Li M, Wang Q, Butler AW, Paul B, Wu HM, Hui TC, Choi SC, So MT, Garcia-Barcelo MM, McAlonan GM, Chen EY, Cheung EF, Chan RC, Purcell SM, Cherny SS, Chen RR, Li T, Sham PC.
Schizophr Bull
View full abstract on Pubmed
Genetic association analysis of 300 genes identifies a risk haplotype in SLC18A2 for post-traumatic stress disorder in two independent samples.
Authors: Solovieff N, Roberts AL, Ratanatharathorn A, Haloosim M, De Vivo I, King AP, Liberzon I, Aiello A, Uddin M, Wildman DE, Galea S, Smoller JW, Purcell SM, Koenen KC.
Neuropsychopharmacology
View full abstract on Pubmed
An inherited duplication at the gene p21 Protein-Activated Kinase 7 (PAK7) is a risk factor for psychosis.
Authors: Morris DW, Pearson RD, Cormican P, Kenny EM, O'Dushlaine CT, Perreault LP, Giannoulatou E, Tropea D, Maher BS, Wormley B, Kelleher E, Fahey C, Molinos I, Bellini S, Pirinen M, Strange A, Freeman C, Thiselton DL, Elves RL, Regan R, Ennis S, Dinan TG, McDonald C, Murphy KC, O'Callaghan E, Waddington JL, Walsh D, O'Donovan M, Grozeva D, Craddock N, Stone J, Scolnick E, Purcell S, Sklar P, Coe B, Eichler EE, Ophoff R, Buizer J, Szatkiewicz J, Hultman C, Sullivan P, Gurling H, Mcquillin A, St Clair D, Rees E, Kirov G, Walters J, Blackwood D, Johnstone M, Donohoe G, O'Neill FA, Kendler KS, Gill M, Riley BP, Spencer CC, Corvin A.
Hum Mol Genet
View full abstract on Pubmed
Statistical power and significance testing in large-scale genetic studies.
Authors: Sham PC, Purcell SM.
Nat Rev Genet
View full abstract on Pubmed
Using XHMM Software to Detect Copy Number Variation in Whole-Exome Sequencing Data.
Authors: Fromer M, Purcell SM.
Curr Protoc Hum Genet
View full abstract on Pubmed
Genetic modifiers and subtypes in schizophrenia: investigations of age at onset, severity, sex and family history.
Authors: Bergen SE, O'Dushlaine CT, Lee PH, Fanous AH, Ruderfer DM, Ripke S, Sullivan PF, Smoller JW, Purcell SM, Corvin A.
Schizophr Res
View full abstract on Pubmed