Dr. Richard Kronauer

In memoriam: Richard E. Kronauer, Ph.D.

Gordon McKay Professor of Mechanical Engineering, Emeritus
Harvard Title

Gordon McKay Professor of Mechanical Engineering, Emeritus

Other Affiliations

Member of the Faculty of the Harvard-MIT Division of Health Sciences and Technology

Biography
Obituary
Selected Publications 

Kronauer RE, St Hilaire MA, Rahman SA, Czeisler CA, Klerman EB. An<
Exploration of the Temporal Dynamics of Circadian Resetting Responses to Short-and Long-Duration Light Exposures: Cross-Species Consistencies and Differences.
J Biol Rhythms. 2019 Oct;34(5):497-514. doi: 10.1177/0748730419862702. Epub 2019. Aug 1. PMID: 31368391.

Cohen DA, Wang W, Wyatt JK, Kronauer RE, Dijk DJ, Czeisler CA, Klerman EB. Uncovering residual effects of chronic sleep loss on human performance.
Sci Transl Med. 2010 Jan 13;2(14):14ra3. doi: 10.1126/scitranslmed.3000458. PMID:20371466; PMCID: PMC2892834.

Gooley JJ, Rajaratnam SM, Brainard GC, Kronauer RE, Czeisler CA, Lockley SW. Spectral responses of the human circadian system depend on the irradiance and duration of exposure to light.
Sci Transl Med. 2010 May 12;2(31):31ra33. doi:10.1126/scitranslmed.3000741. PMID: 20463367; PMCID: PMC4414925.

Klerman H, St Hilaire MA, Kronauer RE, Gooley JJ, Gronfier C, Hull JT, Lockley SW, Santhi N, Wang W, Klerman EB. Analysis method and experimental conditions affect computed circadian phase from melatonin data.
PLoS One.2012;7(4):e33836. doi: 10.1371/journal.pone.0033836. Epub 2012 Apr 12. PMID: 22511928; PMCID: PMC3325223.

Chang AM, Santhi N, St Hilaire M, Gronfier C, Bradstreet DS, Duffy JF, Lockley SW, Kronauer RE, Czeisler CA. Human responses to bright light of different durations.
J Physiol. 2012 Jul 1;590(13):3103-12. doi: 10.1113/jphysiol.2011.226555. Epub 2012 Apr 23. PMID: 22526883; PMCID: PMC3406393.

St Hilaire MA, Gooley JJ, Khalsa SB, Kronauer RE, Czeisler CA, Lockley SW. Human phase response curve to a 1 h pulse of bright white light.
J Physiol. 2012 Jul 1;590(13):3035-45. doi: 10.1113/jphysiol.2012.227892. Epub 2012 Apr 30.PMID: 22547633; PMCID: PMC3406389.

Klerman EB, Wang W, Duffy JF, Dijk DJ, Czeisler CA, Kronauer RE. Survival analysis indicates that age-related decline in sleep continuity occurs exclusively during NREM sleep.
Neurobiol Aging. 2013 Jan;34(1):309-18. doi:10.1016/j.neurobiolaging.2012.05.018. Epub 2012 Jun 23. PMID: 22727943; PMCID: PMC3469724.

Rüger M, St Hilaire MA, Brainard GC, Khalsa SB, Kronauer RE, Czeisler CA,Lockley SW. Human phase response curve to a single 6.5 h pulse of short-wavelength light.
J Physiol. 2013 Jan 1;591(1):353-63. doi:10.1113/jphysiol.2012.239046. Epub 2012 Oct 22. PMID: 23090946; PMCID: PMC3630790.

Rahman SA, St Hilaire MA, Chang AM, Santhi N, Duffy JF, Kronauer RE, Czeisler CA, Lockley SW, Klerman EB. Circadian phase resetting by a single short-duration light exposure. JCI Insight. 2017 Apr 6;2(7):e89494. doi:10.1172/jci.insight.89494. PMID: 28405608; PMCID: PMC5374060.

St Hilaire MA, Klerman EB, Khalsa SB, Wright KP Jr, Czeisler CA, Kronauer RE. Addition of a non-photic component to a light-based mathematical model of the human circadian pacemaker.
J Theor Biol. 2007 Aug 21;247(4):583-99. [PMID: 17531270]

Scheer FA, Wright KP Jr, Kronauer RE, Czeisler CA. Plasticity of the intrinsic period of the human circadian timing system.
PLoS ONE. 2007 Aug 8;2(1):e721. [PMID: 17684566]

Kronauer RE, Gunzelmann G, Van Dongen HP, Doyle FJ 3rd, Klerman EB. Uncovering physiologic mechanisms of circadian rhythms and sleep/wake regulation 
through mathematical modeling.
J Biol Rhythms. 2007 Jun;22(3):233-45. [PMID: 17517913]

Gronfier C, Wright KP Jr, Kronauer RE, Czeisler CA. Entrainment of the human circadian pacemaker to longer-than-24-h days.
Proc Natl Acad Sci U S A. 2007 May 22;104(21):9081-6. [PMID: 17502598]

Indic P, Gurdziel K, Kronauer RE, Klerman EB. Development of a two-dimension manifold to represent high dimension mathematical 
models of the intracellular Mammalian circadian clock.
J Biol Rhythms. 2006 Jun;21(3):222-32. [PMID: 16731662]

Indic P, Forger DB, St Hilaire MA, Dean DA 2nd, Brown EN, Kronauer RE, Klerman
EB, Jewett ME. Comparison of amplitude recovery dynamics of two limit cycle oscillator models of
the human circadian pacemaker.
Chronobiol Int. 2005;22(4):613-29. [PMID: 16147894]

Zeitzer JM, Khalsa SB, Boivin DB, Duffy JF, Shanahan TL, Kronauer RE, Czeisler
CA. Temporal dynamics of late-night photic stimulation of the human circadian timing 
system.
Am J Physiol Regul Integr Comp Physiol. 2005 Sep;289(3):R839-44. [PMID: 15890792]

Klerman EB, Davis JB, Duffy JF, Dijk DJ, Kronauer RE. Older people awaken more frequently but fall back asleep at the same rate as
younger people.
Sleep. 2004 Jun 15;27(4):793-8. [PMID: 15283016]

Gronfier C, Wright KP Jr, Kronauer RE, Jewett ME, Czeisler CA. Efficacy of a single sequence of intermittent bright light pulses for delaying
circadian phase in humans.
Am J Physiol Endocrinol Metab. 2004 Jul;287(1):E174-81. [PMID: 15039146]

Forger DB, Dean DA 2nd, Gurdziel K, Leloup JC, Lee C, Von Gall C, Etchegaray 
JP, Kronauer RE, Goldbeter A, Peskin CS, Jewett ME, Weaver DR. Development and validation of computational models for mammalian circadian
oscillators.
OMICS. 2003 Winter;7(4):387-400. [PMID: 14683611]

Klerman EB, Gershengorn HB, Duffy JF, Kronauer RE. Comparisons of the variability of three markers of the human circadian pacemaker.
J Biol Rhythms. 2002 Apr;17(2):181-93. [PMID: 12002165]